1 00:00:09,509 --> 00:00:07,430 so our guts can tell us a lot about what 2 00:00:11,830 --> 00:00:09,519 stresses us as well as several other 3 00:00:13,830 --> 00:00:11,840 things one study taking place right now 4 00:00:16,070 --> 00:00:13,840 on board the stations getting a look at 5 00:00:18,550 --> 00:00:16,080 the guts of a couple of astronauts to 6 00:00:20,470 --> 00:00:18,560 give an insight into the bacteria in 7 00:00:21,990 --> 00:00:20,480 that area which is known as the 8 00:00:24,150 --> 00:00:22,000 microbiome 9 00:00:26,390 --> 00:00:24,160 and to see how space flight affects it 10 00:00:28,950 --> 00:00:26,400 they also have a ground subject as well 11 00:00:31,269 --> 00:00:28,960 as this is a part of scott kelly and his 12 00:00:32,950 --> 00:00:31,279 twin brother mark's twin study nasa 13 00:00:34,790 --> 00:00:32,960 commentator lori meigs caught up with 14 00:00:36,470 --> 00:00:34,800 the co-investigator of this experiment 15 00:00:41,430 --> 00:00:36,480 to learn more 16 00:00:43,430 --> 00:00:41,440 i'm looking at the bacteria in the gut 17 00:00:46,389 --> 00:00:43,440 of both twins 18 00:00:47,590 --> 00:00:46,399 longitudinally over time 19 00:00:49,750 --> 00:00:47,600 while 20 00:00:51,750 --> 00:00:49,760 one is going to be spending a year in 21 00:00:53,750 --> 00:00:51,760 space and one will be 22 00:00:56,310 --> 00:00:53,760 on the ground 23 00:00:57,430 --> 00:00:56,320 having the twins is very powerful 24 00:01:01,029 --> 00:00:57,440 because 25 00:01:04,390 --> 00:01:01,039 there's growing data that suggests that 26 00:01:07,030 --> 00:01:04,400 the uh genetic makeup of the individual 27 00:01:09,510 --> 00:01:07,040 human actually has a very strong 28 00:01:12,390 --> 00:01:09,520 influence on some of the bacteria that 29 00:01:15,270 --> 00:01:12,400 live in their gut so some 30 00:01:19,109 --> 00:01:15,280 genetic types of humans are better hosts 31 00:01:21,510 --> 00:01:19,119 for some genetic types of bacteria 32 00:01:23,910 --> 00:01:21,520 so we call this microbiome that's called 33 00:01:26,469 --> 00:01:23,920 the microbiome right 34 00:01:28,870 --> 00:01:26,479 microbiome would be all of the microbes 35 00:01:31,670 --> 00:01:28,880 living in a particular 36 00:01:34,069 --> 00:01:31,680 environment in our case it's the gi 37 00:01:36,390 --> 00:01:34,079 tract 38 00:01:38,550 --> 00:01:36,400 but we're focusing really only on the 39 00:01:41,030 --> 00:01:38,560 bacteria which is the vast majority of 40 00:01:43,350 --> 00:01:41,040 the microbes in the gut anyway 41 00:01:45,270 --> 00:01:43,360 we've had other microbiome studies as 42 00:01:46,870 --> 00:01:45,280 well what makes this one different is it 43 00:01:48,950 --> 00:01:46,880 because of the twin situation well the 44 00:01:51,990 --> 00:01:48,960 twins makes it unique 45 00:01:54,389 --> 00:01:52,000 i think the longitudinal aspect we're 46 00:01:55,510 --> 00:01:54,399 going to have an individual in space for 47 00:01:57,510 --> 00:01:55,520 a year 48 00:01:59,749 --> 00:01:57,520 and be able to track what changes are 49 00:02:02,149 --> 00:01:59,759 happening over that course of time so 50 00:02:04,950 --> 00:02:02,159 that's another unique aspect 51 00:02:06,550 --> 00:02:04,960 we really don't know what's 52 00:02:09,510 --> 00:02:06,560 going to happen 53 00:02:11,270 --> 00:02:09,520 with the bacterial diversity 54 00:02:13,589 --> 00:02:11,280 in the gut um 55 00:02:15,430 --> 00:02:13,599 over that long of a period of time what 56 00:02:16,229 --> 00:02:15,440 do we learn from studying this 57 00:02:19,110 --> 00:02:16,239 well 58 00:02:23,830 --> 00:02:19,120 there are a lot of unique stressors but 59 00:02:24,869 --> 00:02:23,840 stress is not unique to space so i think 60 00:02:27,350 --> 00:02:24,879 having 61 00:02:30,070 --> 00:02:27,360 an idea of what's going on with the 62 00:02:33,110 --> 00:02:30,080 bacteria in the gut 63 00:02:36,229 --> 00:02:33,120 in response to stress and having related 64 00:02:39,430 --> 00:02:36,239 measures in terms of 65 00:02:41,509 --> 00:02:39,440 sampling at the same periods of time 66 00:02:43,110 --> 00:02:41,519 having those same 67 00:02:48,390 --> 00:02:43,120 time points 68 00:02:52,070 --> 00:02:49,589 mood 69 00:02:52,949 --> 00:02:52,080 other measures of health 70 00:02:54,470 --> 00:02:52,959 uh 71 00:02:56,470 --> 00:02:54,480 blood pressure 72 00:02:58,949 --> 00:02:56,480 you know what's going on in their lives 73 00:03:00,949 --> 00:02:58,959 are they sleep deprived 74 00:03:03,430 --> 00:03:00,959 having all of those 75 00:03:06,550 --> 00:03:03,440 data to relate to the microbiome will 76 00:03:07,350 --> 00:03:06,560 give us a much richer picture of how 77 00:03:13,830 --> 00:03:07,360 the 78 00:03:16,149 --> 00:03:13,840 and that would be 79 00:03:19,030 --> 00:03:16,159 wonderful information to have for human 80 00:03:20,790 --> 00:03:19,040 health on earth as well as looking 81 00:03:24,309 --> 00:03:20,800 towards longer term 82 00:03:26,550 --> 00:03:24,319 space flight like going to mars 83 00:03:29,270 --> 00:03:26,560 you're a university professor 84 00:03:31,350 --> 00:03:29,280 you have a space station experiment an 85 00:03:32,149 --> 00:03:31,360 international space isn't that wonderful 86 00:03:34,390 --> 00:03:32,159 yeah 87 00:03:36,390 --> 00:03:34,400 so oh that's so exciting i mean when we 88 00:03:38,710 --> 00:03:36,400 found out our project had been selected 89 00:03:40,949 --> 00:03:38,720 for one of these twin studies 90 00:03:42,949 --> 00:03:40,959 you know we were just thrilled beyond 91 00:03:44,710 --> 00:03:42,959 words we couldn't stop telling people 92 00:03:46,949 --> 00:03:44,720 we're stopping colleagues in the 93 00:03:49,350 --> 00:03:46,959 hallways saying we're going to nasa 94 00:03:51,670 --> 00:03:49,360 we're getting a nasa project i mean it's 95 00:03:54,070 --> 00:03:51,680 it's just such a huge thrill and the 96 00:03:56,309 --> 00:03:54,080 nasa people have been so 97 00:03:59,509 --> 00:03:56,319 wonderful to work with they've been so 98 00:04:01,910 --> 00:03:59,519 engaged involved at every step of the